Professor Ambrose O. Isah graduated from the University of  Ibadan Medical School in 1979 and had his residency training in Internal Medicine at the University of Benin Teaching Hospital (Nigeria). He is a Fellow of the National Postgraduate Medical College of Nigeria, the West African College of Physicians and the Royal College of Physicians (Edinburgh)

He had his postgraduate training in Clinical Pharmacology and Therapeutics at the Wolfson Unit of Clinical Pharmacology, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom obtaining his doctorate degree (MD) in 1995. He also attended a training course at the WHO Collaborating Centre for International Drug Monitoring, Uppsala, Sweden in 1996 and spent a Sabbatical year in 2016/17

Professor Isah has served on the academic staff of the University of Benin Medical School since 1989. He is a past Dean of the Medical School as well as Head of the Department of Medicine;  and now Head, Department of Clinical Pharmacology and Therapeutics. He also serves as an external examiner and assessor to several Universities in and outside Nigeria and the Medical Council. He has several publications.

He is a Consultant Physician and Clinical Pharmacologist at the University of Benin Teaching Hospital, Benin City. He is the current Chairman of the Internal Medicine Subspecialty of Clinical Pharmacology and Therapeutics of the West African Postgraduate Medical Colleges and immediate past Chairman of the subspecialty in the National Postgraduate College. He is a Past President of the Nigerian Hypertension Society and past member of the National  Non communicable Disease Committee.

Professor Isah played a key role in the establishment of the Pharmacovigilance system in Nigeria.  He is the current Chairman of the National Drug Safety Advisory Committee  and the Vice President of the African Society of Pharmacovigilance (ASoP). He also served as  Chairman of the National Essential Medicines List/Drug Formulary Committee until recently. He serves on a number of committees of the Federal Ministry of Health; and is also a member of the WHO Expert Panel